Platelet-rich plasma (PRP) injection is a non-operative, injectable management option for a number of musculoskeletal problems, including osteoarthritis. Research is now revealing that PRP is now significantly more superior compared to other injectable options including hyaluronic acid and steroids.[i],[ii],[iii],[iv] Furthermore, given its autologous nature, PRP has very small risk and adverse reaction profile. With these facts in mind, PRP has attracted an increasing amount of interest.
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[i] Cole BJ, Karas V, Hussey K, et al. Hyaluronic Acid Versus PlateletRich Plasma: A Prospective, DoubleBlind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intraarticular Biology for the Treatment of Knee Osteoarthritis. Am J Sports Med. 2017 Feb;45(2):339346.
[ii] Meheux CJ, McCulloch PC, Lintner DM, et al. Efficacy of Intra-articular Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review. Arthroscopy. 2016 Mar;32(3):495-505.
[iii] Mi B, Liu G, Zhou W, et al. Platelet rich plasma versus steroid on lateral epicondylitis: meta-analysis of randomized clinical trials. Phys Sportsmed. 2017 May;45(2):97-104.
[iv] Raeissadat SA, Rayegani SM, Hassanabadi H, et al. Knee Osteoarthritis Injection Choices: Platelet- Rich Plasma (PRP) Versus Hyaluronic Acid (A one-year randomized clinical trial). Clin Med Insights Arthritis Musculoskelet Disord. 2015 Jan 7;8:1-8.
[v] Xie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014 Feb 25;16(1):204.
[vi] Muchedzi TA1, Roberts SB2. A systematic review of the effects of platelet rich plasma on outcomes for patients with knee osteoarthritis and following total knee arthroplasty. Surgeon. 2018 Aug;16(4):250-258.
[vii] Glynn LG1, Mustafa A1, Casey M1, Krawczyk J, et al. Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot Feasibility Stud. 2018 Jul 4;4:93.